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Speaker: John Paul SanGiovanni, Sc.D.
University of Arizona
Associate Professor, Nutritional Sciences
Dr. John Paul SanGiovanni directs the Center for the Study of Nutrient-Responsive Systems. He joined the University of Arizona Department of Nutritional Sciences, Precision Nutrition and Wellness Initiative and BIO5 in the fall of 2019 after nearly twenty years as a scientist at the National Institutes of Health. Dr. SanGiovanni trained as a scholar and researcher in neuroscience, visual psychophysics, nutritional biochemistry, biostatistics, and epidemiologic research design at Harvard University, Brandeis University, and Boston College. He earned his master and doctoral degrees from Harvard University. Profiles may be found on NeuroTree LinkedIn and Google Scholar.
Dr. SanGiovanni’s teams work to advance knowledge on individual differences in nutrient sensing, transport, metabolism and nutrient-related signaling processes as a means to inform rational planning of effective interventions aimed at the enhancement of human health, extension of life and reduction of illness and disability.
At NIH, Dr. SanGiovanni acted as a central leader of teams advancing knowledge on the role of conditionally essential tissue-resident nutrients in health and disease of the retina and brain. His achievements span multi-center clinical trials that led to standard-of-care treatments for age-related degeneration (JAMA, 2013) to the first successful genome-wide association study on complex disease (Science, 2006) to mechanistic in vivo model-based studies elucidating actions of diet-based fatty acids in the retina (Nature Medicine, 2007). He received NIH Director’s Award from Dr. Elias Zerhouni in 2008 and Dr. Francis Collins in 2011 for his key contributions in developing the first resource in the NIH Database on Genotype and Phenotype (dbGaP) – in 2010 he was awarded the Norman Salem Jr. Early Career Award from the International Society on the Study of Fatty Acids and Lipids. Dr. SanGiovanni has published in Science (cover feature), Nature Medicine (cover feature), Science Translational Medicine, JAMA, PNAS, J. Neurosci., Pediatrics, FASEB Journal, Circulation, Oncotarget, and American Journal of Clinical Nutrition. His works have been cited over 16,000 times. He has six works with over 650 citations, two works with over 2500 citations and one work with over 4000.
Dr. SanGiovanni’s research program at the University has three dominant themes developed to yield necessary information for rational planning of public health interventions using precision nutrition. He is using integrative omics technologies to: 1) characterize and catalog structural chemistry and molecular dynamics of nutrient-responsive human systems (receptors, transporters, enzymes and hormones); and, 2) determine functional implications of structural variation in elements of these systems. He is using techniques in physiological optics to characterize in vivo human response to nutrient intake (with a focus on tissue status change and retinal | visual function). He will identify and characterize mechanisms and rate-limiting steps of nutrient sensing and signaling in human retina and brain using techniques in membrane and organoid biophysics.
· 2000 – 2019 Scientist, NIH
· 1999 Sc.D. – Harvard University
· 1994 M.A. – Harvard University
· 1993 M.S. – Brandeis University
· 1988 – 1993 – Training, Harvard Med. School
· 1988 A.B. – Boston College